期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 280, 期 1-2, 页码 1-5出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2007.08.016
关键词
nuclear receptor; transcription; chromatin; coactivator; nucleosome
资金
- Intramural NIH HHS [Z99 ES999999, Z01 ES071006-09] Funding Source: Medline
The mechanisms and interplay of coactivators that underlie transcription activation is a critical avenue of investigation in biology today. Using nuclear receptor (NR) mediated transcription activation as a model, the nature of coactivator recruitment and chromatin modifications has been found to be highly dynamic. Progress in understanding the kinetics and regulation of coactivator recruitment, and subsequent effects on transcriptional readout, has greatly improved our understanding of nuclear receptor mediated transcription, the subject of discussion in this 'At the Cutting Edge' review. Published by Elsevier Ireland Ltd.
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