期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 296, 期 1-2, 页码 87-93出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2008.07.019
关键词
Estrogen; Parkinson's disease; Western blot analysis; Dopamine system; Mice
资金
- Ministry of Science and Education in Japan [136700627, 13671095]
- Grants-in-Aid for Scientific Research [13671095] Funding Source: KAKEN
Emerging evidence shows a beneficial effect of estrogens for Parkinson's disease, yet the exact potency of these compounds implicated remain obscured. In this Study, we investigated the neuroprotective effect of 17 beta-estradiol and estrone against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal toxicity in mice. The neuroprotective effects of both compounds were evaluated by HPLC and Western blot analyses 5 days after the last of 4 consecutive injections of MPTP at 1-h intervals to mice. Subacute treatment (10 days) with estrone or 17 beta-estradiol at low doses (0.05 and 0.2 mg/kg) showed no significant changes against MPTP-induced damage of striatal dopamine terminals in mice. Furthermore, acute treatment with estrone at high doses (0.5 and 2.0 mg/kg) showed no significant alterations against MPTP-induced damage of striatal dopamine terminals in mice. In contrast, acute treatment with 17 beta-estradiol at high doses exhibited a neuroprotective effect against the damage of striatal dopamine terminals in both male and female mice after MPTP treatments. The results demonstrate that estrogen therapy with high doses may have a neuroprotective effect on the damage of striatal dopamine terminals in the MPTP-induced mice. These findings may lead to be development of estrogen therapy for the prevention and treatment of Parkinson's disease. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据