期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 396, 期 1-2, 页码 79-85出版社
SPRINGER
DOI: 10.1007/s11010-014-2144-x
关键词
Malonyldialdehyde; Glyoxal; Oxidative stress; Shear stress; Low density lipoproteins; Endotheliocytes
类别
资金
- Russian Foundation for Basic Research [13-04-01092]
Under some pathological conditions, the natural dicarbonyl compounds can accumulate in the blood. The examples are malonyldialdehyde (MDA) formed as a secondary product of lipid peroxidation of unsaturated fatty acids during atherosclerosis, and glyoxal (GOX), a homolog of MDA, which accumulates during glucose autoxidation in patients with diabetes mellitus. This study compared the influence of both dicarbonyl compounds on low-density lipoproteins (LDL) and the membrane of endotheliocytes. In comparison with GOX, MDA induced more pronounced changes in physical and chemical properties of LDL particles. On the other hand, GOX-modified LDL particles were more prone to oxidation and aggregation than MDA-modified LDL. Incubation of endotheliocytes with MDA increased cell mechanical stiffness in contrast to incubation with GOX, which decreased it.
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