期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 380, 期 1-2, 页码 107-119出版社
SPRINGER
DOI: 10.1007/s11010-013-1664-0
关键词
MiR-126; Colon cancer; Cancer proliferation; Cancer metastasis; RhoA
类别
资金
- National Natural Science Foundation [81272736]
- Natural Science Foundation of Hunan Province [09JJ3066]
- Science and Technology of Hunan Province [2009FJ3086]
- Innovative Project of Science and Technology of Hunan Province [2011TT2020]
Recent data strongly suggests the profound role of miRNAs in cancer progression. Here, we showed miR-126 expression was much lower in HCT116, SW620 and HT-29 colon cancer cells with highly metastatic potential and miR-126 downregulation was more frequent in colorectal cancers with metastasis. Restored miR-126 expression inhibited HT-29 cell growth, cell-cycle progression and invasion. Mechanically, microarray results combined with bioinformatic and experimental analysis demonstrated miR-126 exerted cancer suppressor role via inhibiting RhoA/ROCK signaling pathway. These results suggest miR-126 function as a potential tumor suppressor in colon cancer progression and miR-126/RhoA/ROCK may be a novel candidate for developing rational therapeutic strategies.
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