期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 374, 期 1-2, 页码 13-20出版社
SPRINGER
DOI: 10.1007/s11010-012-1498-1
关键词
Mesenchymal stem cells (MSCs); Aging; Wnt/beta-catenin signaling; ROS
类别
资金
- Teachers Research Fund of Zhejiang University City College [J-12019, J-12021]
- Student Research Fund of Zhejiang University City College [XZ2012562091, X2012562098]
- Zhejiang Provincial Foundation of National Science [LQ12H31001]
- Science Research Foundation of the Zhejiang Health Bureau [2012KYA068, 2012KYB066]
Recent studies have demonstrated that the Wnt/beta-catenin signaling plays an important role in stem cell aging. However, the mechanisms of cell senescence induced by Wnt/beta-catenin signaling are still poorly understood. Our preliminary study has indicated that activated Wnt/beta-catenin signaling can induce MSC aging. In this study, we reported that the Wnt/beta-catenin signaling was a potent activator of reactive oxygen species (ROS) generation in MSCs. After scavenging ROS with N-acetylcysteine, Wnt/beta-catenin signaling-induced MSC aging was significantly attenuated and the DNA damage and the expression of p16(INK4A), p53, and p21 were reduced in MSCs. These results indicated that the Wnt/beta-catenin signaling could induce MSC aging through promoting the intracellular production of ROS, and ROS may be the main mediators of MSC aging induced by excessive activation of Wnt/beta-catenin signaling.
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