期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 353, 期 1-2, 页码 59-63出版社
SPRINGER
DOI: 10.1007/s11010-011-0774-9
关键词
Atherosclerosis; CKD; Homocysteine; LDL; Ox-LDL; Ox-LDL-AB
类别
资金
- Andalusian Regional Government (Endocrinology & Metabolism Group)
- [BFU2008-05340]
To study atherogenesis markers in patients with stage 5D chronic kidney disease (CKD-5D) on hemodialysis to determine which parameters are modified and whether their behavior differ between male and female patients of similar age. Total cholesterol, triglycerides, glucose, total proteins, HDL-cholesterol, LDL-cholesterol, oxidative modification of low-density lipoprotein-cholesterol, autoantibodies against oxidized low-density lipoproteins-cholesterol, homocysteine (Hcy), folate, and vitamin B12 were measured in male and female controls and CKD-5D patients on hemodialysis for > 6 months. The CKD-5D patients had significantly lower cholesterol, LDL-c and ox-LDL levels and significantly higher ox-LDL-AB and Hcy levels versus their respective controls. The reduction in ox-LDL in CKD patients does not imply a lower risk of atherosclerosis. In fact, the risk may be higher due to a greater capture of ox-LDL by macrophage scavenger receptors, which are increased in these patients. Elevated Hcy levels may also be a risk factor for atherosclerosis in male and female CKD-5D patients.
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