期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 362, 期 1-2, 页码 1-6出版社
SPRINGER
DOI: 10.1007/s11010-011-1120-y
关键词
SNIP1; Nuclear localization; HSE signaling pathway; HSP
类别
资金
- National 973 program of China [2004CB518605]
- National 863 project of China [2006AA020501]
- National Key Sci-Tech Special Project of China [2008ZX10002-020]
- Shanghai Municipal Science and Technology Commission [03dz14086]
- National Natural Science foundation of China [30024001, 30771188]
In the last 10 years, more and more attention has been focused on SNIP1 (Smad nuclear interacting protein 1), which functions as a transcriptional coactivator. We report here that through quantitative real-time PCR analysis in 18 different human tissues, SNIP1 was found to be expressed ubiquitously. When overexpressed in HeLa cells, SNIP1-EGFP fused protein exhibited a nuclear localization with a characteristic subnuclear distribution in speckles or formed larger discrete nuclear bodies in some cells. Reporter gene assay showed that overexpression of SNIP1 in HEK 293 cells or H1299 cells strongly activated the HSE signaling pathway. Moreover, SNIP1 could selectively regulate the transcription of HSP70A1A and HSP27. Taken together, our findings suggest that SNIP1 might also be a positive regulator of HSE signaling pathway.
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