期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 195, 期 1, 页码 10-13出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbiopara.2014.05.004
关键词
Plasmodium; Mosquito stages; Plasmepsins; Aspartic proteases
资金
- DST [SR/SO/HS-122/2008]
- DBT
- Department of Biotechnology (DBT, India)
- Bioinformatics Infrastructure Facility (BIF) at ICGEB
- CSIR-CDRI
Plasmepsins (PM), aspartic proteases of Plasmodium, comprises a family of ten proteins that perform critical functions in Plasmodium life cycle. Except VII and VIII, functions of the remaining plasmepsin members have been well characterized. Here, we have generated a mutant parasite lacking PM VII in Plasmodium berghei using reverse genetics approach. Systematic comparison of growth kinetics and infection in both mosquito and vertebrate host revealed that PM VII depleted mutants exhibited no defects in development and progressed normally throughout the parasite life cycle. These studies suggest a dispensable role for PM VII in Plasmodium berghei life cycle. (C) 2014 Elsevier B.V. All rights reserved.
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