期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 172, 期 2, 页码 57-65出版社
ELSEVIER
DOI: 10.1016/j.molbiopara.2010.03.019
关键词
Malaria; Plasmodium; Gametocyte; Parasite; Drug; Differentiation
资金
- Wellcome Trust
- European Commission
- UK Medical Research Council
Male and female gametocytes are the components of the malaria parasite life cycle which are taken up from an infected host bloodstream by mosquitoes and thus mediate disease transmission. These gamete precursors are morphologically and functionally quite distinct from their asexual blood stage counterparts and this is reflected in their distinct patterns of gene expression, cellular development and metabolism. Recent transcriptome, proteome and reverse genetic studies have added valuable information to that obtained from traditional studies. However, we still have no answer to the fundamental question regarding sexual development: 'what triggers gametocytogenesis'? In the current climate of eradication/elimination, tackling transmission by killing gametocytes has an important place on the agenda because most antimalarial drugs, whilst killing asexual blood stage parasites, have no effect on the transmissible stages. (C) 2010 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据