期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 172, 期 2, 页码 149-151出版社
ELSEVIER
DOI: 10.1016/j.molbiopara.2010.03.020
关键词
Phosphoinositides; Complementation; P. falciparum; Kinase
资金
- European Commission through the European Network of Excellence
- German Research Council
Phosphoinositides comprise a group of essential phospholipids that control a variety of cellular functions. In the case of the human malaria parasite Plasmodium falciparum, phosphoinositides have been shown to trigger exflagellation and to affect haemoglobin endocytosis and maturation of the parasite's digestive vacuole. A central enzyme in the formation of phosphoinositides is the phosphatidylinositol 4-kinase that catalyzes the production of phosphatidylinositol 4-phosphate from phosphatidylinositol. Here we have identified and characterized a phosphatidylinositol 4-kinase from P. falciparum. Our data show that the corresponding P. falciparum gene, termed PFE0485w, can functionally complement a yeast temperature-sensitive pik1 mutation. Our data add to the concept that P. falciparum maintains its own phospholipids biosynthesis pathway. (C) 2010 Elsevier B.V. All rights reserved.
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