期刊
MOLECULAR & CELLULAR TOXICOLOGY
卷 14, 期 4, 页码 437-444出版社
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
DOI: 10.1007/s13273-018-0048-7
关键词
Marine medaka; 4-Nonylphenol; Toxicity; Embryo; Larvae
资金
- Incheon National University [2015-1410]
BackgroundsNonylphenol (NP) is a hydrophobic xenobiotic compound classified as an endocrine disrupting chemical (EDC) and accumulates in environmental compartments owing to its extensive use. In this study, the detrimental effects of 4-nonylphenol (4-NP) were investigated in marine medaka (Oryzias javanicus) embryos and novel insights into their toxicities are provided.MethodsFollowing exposure to different concentrations of 4-NP (200-1000 g/L), the mortality, hatching rate, and survival rate of larvae were measured. Biochemical endpoints, including intracellular oxidative stress, apoptosis, antioxidant defense, and vitellogenin level, were analyzed to assess the toxicity and endocrine disrupting potential of 4-NP.Results4-NP treatment during post fertilization reduced hatching rate in a dose-dependent manner. Exposure to waterborne 4-NP induced oxidative stress and dysfunction of antioxidant defense systems, which led to apoptotic cellular death. In hatched larvae, the survival rate decreased as vitellegenin level with increasing exposure concentrations owing to persistent 4-NP.ConclusionOur study provides evidence of cellular stress induction/toxicity caused by 4-NP and endocrine disrupting potential in marine medaka embryos.
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