The effects of TiO2 nanoparticles on the protein expression in mouse lung

In this study, the differentially expressed proteins by titanium dioxide nanoparticles (TiO2 NPs) in mouse lung were examined via proteomic approach to better understand the molecular mechanism by which TiO2 NPs could induce toxicities at the protein level. We identified eight proteins that exhibited more than two-fold changes in expression by TiO2 NPs. Of these, five proteins, named cytoplasmic aconitase, L-lactate dehydrogenase A chain, carbonic anhydrase 1, pyruvate kinase isoform M2 and peroxiredoxin 6 displayed increased intensities in TiO2 NP-exposed lungs, while three proteins, named heat shock protein, moesin and apolipoprotein A-1 precursor, showed reduced intensities.