期刊
MOLECULAR & CELLULAR PROTEOMICS
卷 17, 期 12, 页码 2496-2507出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/mcp.RA118.000880
关键词
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资金
- Netherlands Organization for Scientific Research through a VIDI grant [723.013.008]
- Roadmap Initiative Proteins@Work - Netherlands Organization for Scientific Research [184.032.201]
- MSMed program - European Union's Horizon 2020 Framework Programme [686547]
The rapid emergence of antimicrobial resistance is a major threat to human health. Antibiotics modulate a wide range of biological processes in bacteria and as such, the study of bacterial cellular signaling could aid the development of urgently needed new antibiotic agents. Due to the advances in bacterial phosphoproteomics, such a systemwide analysis of bacterial signaling in response to antibiotics has recently become feasible. Here we present a dynamic view of differential protein phosphorylation upon antibiotic treatment and antibiotic resistance. Most strikingly, differential phosphorylation was observed on highly conserved residues of resistance regulating transcription factors, implying a previously unanticipated role of phosphorylation mediated regulation. Using the comprehensive phosphoproteomics data presented here as a resource, future research can now focus on deciphering the precise signaling mechanisms contributing to resistance, eventually leading to alternative strategies to combat antimicrobial resistance.
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