期刊
MOLECULAR & CELLULAR PROTEOMICS
卷 13, 期 10, 页码 2584-2592出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/mcp.M114.040113
关键词
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资金
- Swedish Brain Power Consortium
- Swedish Alzheimer Foundation
- Demensfonden
- Eivind och Elsa K:son Sylvans stiftelse
- Martha och Gustaf Agrens stiftelse
- Gun och Bertil Stohnes Foundation
- Stiftelsen Gamla Tjanarinnor and Svenska Lakaresallskapet
- Canadian Institutes of Health Research [MOP-14037, CBG-101827]
- Ahlen-stiftelsen
- MRC [MC_U132692719] Funding Source: UKRI
- Medical Research Council [MC_U132692719] Funding Source: researchfish
We report a novel strategy for studying synaptic pathology by concurrently measuring levels of four SNARE complex proteins from individual brain tissue samples. This method combines affinity purification and mass spectrometry and can be applied directly for studies of SNARE complex proteins in multiple species or modified to target other key elements in neuronal function. We use the technique to demonstrate altered levels of presynaptic proteins in Alzheimer disease patients and prion-infected mice.
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