期刊
MOLECULAR & CELLULAR PROTEOMICS
卷 9, 期 8, 页码 1689-1702出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/mcp.R110.000067
关键词
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资金
- National Institutes of Health [R01 GM54762, U54 RR022220, PN2 EY016525, R01 GM083960]
- Clore Foundation
- Weizmann Institute
- Sandler Family Supporting Foundation
- National Science Foundation [IIS-0705196]
- Ron Conway
- Mike Homer
- Hewlett-Packard
- NetApp
- IBM
- Intel
Proteomics techniques have been used to generate comprehensive lists of protein interactions in a number of species. However, relatively little is known about how these interactions result in functional multiprotein complexes. This gap can be bridged by combining data from proteomics experiments with data from established structure determination techniques. Correspondingly, integrative computational methods are being developed to provide descriptions of protein complexes at varying levels of accuracy and resolution, ranging from complex compositions to detailed atomic structures. Molecular & Cellular Proteomics 9:1689-1702, 2010.
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