期刊
MODERN RHEUMATOLOGY
卷 27, 期 3, 页码 529-532出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14397595.2014.990409
关键词
Cyclophosphamide; Pericarditis; Systemic lupus erythematosus; Tocilizumab
类别
资金
- Chugai Pharmaceutical
We report on a 41-year-old woman with refractory systemic lupus erythematosus with massive pericarditis, macrophage activation syndrome, and glomerulonephritis despite high-dose glucocorticoids and tacrolimus. Tocilizumab dramatically improved pericarditis, and glomerulonephritis was controlled after adding cyclophosphamide. We had to halt tocilizumab and cyclophosphamide due to possible pneumocystis infection after five and three infusions of tocilizumab and intravenous cyclophosphamide, respectively. Nevertheless, no lupus flare had been observed on glucocorticoid monotherapy and enabled further rapid tapering prednisolone.
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