期刊
MODERN RHEUMATOLOGY
卷 23, 期 5, 页码 884-890出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/s10165-012-0755-1
关键词
Angiopoietin-2; Interstitial lung disease; Intravenous pulse cyclophosphamide; Systemic sclerosis
类别
资金
- Ministry of Health, Labour, and Welfare of Japan
Angiopoietin-2 (Ang2) regulates the transition between vascular quiescence and angiogenesis in a context-dependent manner. In systemic sclerosis (SSc), serum Ang2 levels correlate with its disease activity. Therefore, we investigated the clinical significance of monitoring serum Ang2 levels during intravenous pulse cyclophosphamide (IVCY) therapy in SSc patients with interstitial lung disease (ILD). Serum Ang2 levels were determined by a specific enzyme-linked immunosorbent assay in seven SSc patients treated with IVCY and 20 healthy controls. In the patient group, serum samples were drawn the day before each IVCY therapy. Serum Ang2 levels tended to be higher in SSc patients before IVCY than in healthy controls and significantly correlated with KL-6, surfactant protein D, erythrocyte sedimentation rate, and C-reactive protein in SSc patients with ILD. In sera drawn before the last IVCY, Ang2 levels were significantly decreased compared with initial levels. Notably, Delta serum Ang2 levels between baseline and after the first IVCY significantly correlated with Delta ILD score between before and after the entire IVCY therapy (r = 0.90, p < 0.01). Monitoring Ang2 levels during IVCY treatment may be useful to evaluate and predict the efficacy of this treatment for SSc-ILD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据