期刊
MODERN PATHOLOGY
卷 27, 期 1, 页码 128-134出版社
SPRINGERNATURE
DOI: 10.1038/modpathol.2013.107
关键词
carcinoma; CTNNB1; endometrial; endometrioid; mutations; ovarian; PTEN
类别
资金
- British Columbia (BC) Cancer Foundation
- Vancouver General Hospital (VGH)-University of British Columbia Hospital Foundation
- Canadian Institutes of Health Research (CIHR)
- Washington University [RO1CA71754, P50CA134254]
- NATIONAL CANCER INSTITUTE [R01CA071754, P50CA134254] Funding Source: NIH RePORTER
Ovarian endometrioid carcinomas and endometrial endometrioid carcinomas share many histological and molecular alterations. These similarities are likely due to a common endometrial epithelial precursor cell of origin, with most ovarian endometrioid carcinomas arising from endometriosis. To directly compare the mutation profiles of two morphologically similar tumor types, endometrial endometrioid carcinomas (n = 307) and ovarian endometrioid carcinomas (n = 33), we performed select exon capture sequencing on a panel of genes: ARID1A, PTEN, PIK3CA, KRAS, CTNNB1, PPP2R1A, TP53. We found that PTEN mutations are more frequent in low-grade endometrial endometrioid carcinomas (67%) compared with low-grade ovarian endometrioid carcinomas (17%) (P<0.0001). By contrast, CTNNB1 mutations are significantly different in low-grade ovarian endometrioid carcinomas (53%) compared with low-grade endometrial endometrioid carcinomas (28%) (P<0.0057). This difference in CTNNB1 mutation frequency may be reflective of the distinct microenvironments; the epithelial cells lining an endometriotic cyst within the ovary are exposed to a highly oxidative environment that promotes tumorigenesis. Understanding the distinct mutation patterns found in the PI3K and Wnt pathways of ovarian and endometrial endometrioid carcinomas may provide future opportunities for stratifying patients for targeted therapeutics.
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