期刊
MITOCHONDRION
卷 19, 期 -, 页码 105-112出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2014.07.005
关键词
Mesenchymal stem cells; Hypoxia; Mitochondria; Cell death
资金
- Russian Science Foundation [14-25-00056, 14-15-00463, 14-15-00693]
- Swedish Cancer Society [130463]
- Stockholm Cancer Society [121252]
- Swedish Childhood Cancer Foundation [12/043]
- Swedish Research Council [B0436801]
- Russian Science Foundation [14-15-00693, 14-15-00463] Funding Source: Russian Science Foundation
Multipotent mesenchymal stromal cells (MSCs) are involved in the organization and maintenance of tissue integrity. MSCs have also attracted attention as a promising tool for cell therapy and regenerative medicine. However, their usage is limited due to cell impairment induced by an extremely harsh microenvironment during transplantation ex vivo. The microenvironment of MSCs in tissue depots is characterized by rather low oxygen consumption, demonstrating that MSCs might be quite resistant to oxygen limitation. However, accumulated data revealed that the response of MSCs to hypoxic conditions is rather controversial, demonstrating both damaging and ameliorating effects. Here, we make an attempt to summarize recent knowledge on the survival of MSCs under low oxygen conditions of varying duration and severity and to elucidate the mechanisms of MSC resistance/sensitivity to hypoxic impact. (C) 2014 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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