期刊
MITOCHONDRION
卷 14, 期 -, 页码 42-48出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2013.11.001
关键词
Mitochondrial biogenesis; Oxidative stress; NIR light; Reactive oxygen species; Photobiomodulation
资金
- College of Health and Human Performance
- Department of Applied Physiology and Kinesiology at the University of Florida (UF)
Near-infrared (NIR) light is a complementary therapy used to treat musculoskeletal injuries but the underlying mechanisms are unclear. Acute NIR light treatment (similar to 800-950 nm; 22.8 J/cm(2)) induced a dose-dependent increase in mitochondrial signaling (AMPK, p38 MAPK) in differentiated muscle cells. Repeated NIR light exposure (4 days) appeared to elevate oxidative stress and increase the upstream mitochondrial regulatory proteins AMPK (3.1-fold), p38 (2.8-fold), PGC-1 alpha (19.7%), Sirtl (26.8%), and reduced RIP140 (23.2%), but downstream mitochondrial regulation/content (Tfam, NRF-1, Sirt3, cytochrome c, ETC subunits) was unaltered. Our data indicates that NIR light alters mitochondrial biogenesis signaling and may represent a mechanistic link to the clinical benefits. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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