期刊
MITOCHONDRION
卷 13, 期 6, 页码 862-870出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2013.07.002
关键词
Physical activity; Liver disease; Bioenergetics; Oxidative damage
资金
- Portuguese Foundation for Science and Technology (FCT) [SFRH/BPD/4225/2007, SFRH/BD/2352/2009, SFRH/BPD/66935/2009]
- COMPETE/FEDER/National funds
- FCT [PTDC/DES/113580/2009-FCOMP-01-0124-FEDER-014705]
- Research Centre in Physical Activity, Health and Leisure UID [PEst-OE/SAU/UI0617/2011]
Liver steatosis (non-alcoholic fatty liver disease, NAFLD) is deemed as the hepatic face of the metabolic syndrome, with both physical inactivity and hypercaloric/unbalanced diet, together with increasing age playing a role as predisposing factors. Consequently, one of the most effective strategies used to counteract this scenario is physical exercise. Given the importance of redox signaling in cellular remodeling, in which mitochondria are closely implicated along with important roles on substrate oxidation, here we briefly review the effects of both acute and chronic forms of physical exercise on the modulation of hepatic redox state, highlighting the relevance of mitochondrial metabolism and function in the induction of liver phenotypes that antagonize metabolic alterations associated with liver metabolic diseases. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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