期刊
MITOCHONDRION
卷 12, 期 1, 页码 144-148出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2011.06.015
关键词
Reactive oxygen species; Differentiation; Skeletal muscle; Respiratory chain
资金
- Deutsche Forschungsgemeinschaft [SFB-TR3 A11, D12]
- BMBF [01GM0868]
- Polish Ministry of Science and Higher Education [IP 0237 70]
Myogenesis is accompanied by an intensive metabolic remodeling. We investigated the mitochondrial reactive oxygen species (ROS) generation at different levels of skeletal muscle differentiation: in C2C12 myoblasts, in C2C12 myotubes and in adult mouse skeletal muscle. Differentiation was accompanied by an increase in mitochondrial content and respiratory chain activity. The detected ROS production levels correlated with mitochondrial content, being the lowest in the myoblasts. Unlike the adult skeletal muscle, myoblast ROS production was significantly stimulated by the complex I inhibitor rotenone. Our results show that mitochondria are an important ROS source in skeletal muscle cells. The substantial changes in mitochondrial ROS synthesis during skeletal muscle differentiation can be explained by intensive bioenergetic remodeling. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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