期刊
MITOCHONDRION
卷 12, 期 1, 页码 46-56出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2011.05.003
关键词
Cytochrome c oxidase subunit IV isoform; Mitochondrial membrane potential; Neurodegenerative diseases; Reactive oxygen species; Regulatory subunits; Respiratory control
资金
- Deutsche Forschungsgemeinschaft [AR 343/4-1]
Mitochondrial dysfunction is increasingly recognized as a major factor in the etiology and progression of numerous human diseases, such as (neuro-)degeneration, ischemia reperfusion injury, cancer, and diabetes. Cytochrome c oxidase (COX) represents the rate-limiting enzyme of the mitochondrial respiratory chain and is thus predestined for being a central site of regulation of oxidative phosphorylation, proton pumping efficiency, ATP and reactive oxygen species production, which in turn affect cell signaling and survival. A unique feature of COX is its regulation by various factors and mechanisms interacting with the nucleus-encoded subunits, whose actual functions we are only beginning to understand. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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