期刊
MITOCHONDRION
卷 11, 期 2, 页码 273-278出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2010.10.003
关键词
Mitochondrion; Mitochondrial genome; Eimeria; Plasmodium; Apicomplexa; Nuclear mitochondrial DNA
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [18073013]
- Japan Society for Promotion of Sciences [18GS03140013, 20390120]
- Grants-in-Aid for Scientific Research [20390120, 18073013] Funding Source: KAKEN
Apicomplexan parasites of the genus Plasmodium, pathogens causing malaria, and the genera Babesia and Theileria, aetiological agents of piroplasmosis, are closely related. However, their mitochondrial (mt) genome structures are highly divergent: Plasmodium has a concatemer of 6-kb unit and Babesia/Theileria a monomer of 6.6- to 8.2-kb with terminal inverted repeats. Fragmentation of ribosomal RNA (rRNA) genes and gene arrangements are remarkably distinctive. To elucidate the evolutionary origin of this structural divergence, we determined the mt genome of Eimeria tenella, pathogens of coccidiosis in domestic fowls. Analysis revealed that E. tenella mt genome was concatemeric with similar protein-coding genes and rRNA gene fragments to Plasmodium. Copy number was 50-fold of the nuclear genome. Evolution of structural divergence in the apicomplexan mt genomes is discussed. (C) 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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