期刊
MITOCHONDRION
卷 11, 期 2, 页码 279-286出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2010.10.007
关键词
Astrocytes; Endoplasmic reticulum; 78 kDa glucose-regulated protein (GRP78/HSPA5/BiP); Ischemia; Mitochondria
资金
- NIH [GM 49831, CA27607, DK 079999]
Ca2+ transfer from endoplasmic reticulum (ER) to mitochondria at contact sites between the organelles can induce mitochondrial dysfunction and programmed cell death after stress. The ER-localized chaperone glucose-regulated protein 78 kDa (GRP78/BiP) protects neurons against excitotoxicity and apoptosis. Here we show that overexpressing GRP78 protects astrocytes against ischemic injury, reduces net flux of Ca2+ from ER to mitochondria, increases Ca2+ uptake capacity in isolated mitochondria, reduces free radical production, and preserves respiratory activity and mitochondrial membrane potential after stress. We conclude that GRP78 influences ER-mitochondrial Ca2+ crosstalk to maintain mitochondrial function and protect astrocytes from ischemic injury. (C) 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据