期刊
MITOCHONDRION
卷 11, 期 1, 页码 207-213出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2010.09.011
关键词
OXPHOS capacity; mtDNA; Tissue-specificity; Copy number
资金
- Instituto de Salud Carlos III-FIS [PI07/0045]
- Ministerio de Ciencia y Tecnologia [BMC2001-2421, SAF2009-08007, CSD2007-00020]
- Diputacion General de Aragon [B33, B55]
- Marie Curie European Reintegration Grant [PERG04-GA-2008-239372]
- Gobierno de Aragon [B015/2001]
- Ministerio de Ciencia e Innovacion [JCI-2008-02648]
Each cell type develops and maintains a specific oxidative phosphorylation (OXPHOS) capacity to satisfy its metabolic and energetic demands. This implies that there are differences between tissues in mitochondrial number, function, protein composition and morphology. The OXPHOS system biogenesis requires the coordinated expression of both mitochondrial and nuclear genomes. Mitochondrial DNA (mtDNA) expression can be regulated at different levels (replication, transcription, translation and post-translational levels) to contribute to the final observed OXPHOS activities. By analyzing five mammalian tissues, we evaluated the differences in the cellular amount of mtDNA and its correlation with the final observed mitochondrial activity. (C) 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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