期刊
MITOCHONDRION
卷 11, 期 6, 页码 867-870出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2011.06.009
关键词
Cerebrospinal fluid; Choroid plexus dysfunction; Homovanillic acid; Kearns-Sayre syndrome; Selenium
资金
- ISCIII-MICIN
- FIS (ISCIII) [PI07/0548, PI080663, PS09/01132, PI10/00662, EC07/90095]
Our aim was to assess biochemical parameters to detect choroid plexus dysfunction in Kearns-Sayre syndrome (KSS) patients. We studied CSF from 7 patients with KSS including total proteins. 5-methyltetrahydrofolate, homovanillic acid (HVA) and Selenium (Se) concentrations. High Se values, increased HVA and total protein concentrations and decreased 5-MTHF values were observed in all cases. This pattern seems very specific to KSS since it was only detected in 7 patients out of 1850 CSF samples analysed, and may represent a good biochemical model for evaluating choroid plexus dysfunction. The accumulated Se in CSF might have deleterious consequences such as toxicity effects. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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