期刊
MITOCHONDRION
卷 10, 期 4, 页码 309-315出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2010.01.005
关键词
Mitophagy; Autophagy; Mitochondria; Adipocyte; Reticulocyte
资金
- NCI NIH HHS [R01 CA116088-01A1, R01 CA116088] Funding Source: Medline
- NIA NIH HHS [R01 AG030081-01A1, R01 AG030081] Funding Source: Medline
The cellular process of macromolecular degradation known as macroautophagy has long been known to play a role in the elimination of mitochondria. Over the past decade, much progress has been made in the development of systems by which the nature and mechanism of mitochondria degradation may be studied. Recent findings imply that the degradation of mitochondria via autophagy may be more specific and more tightly regulated than originally thought, and have led to designation of this specific type of autophagy as mitophagy. In this review we provide a brief history of the development of mitophagy models and their associated discoveries. (C) 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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