期刊
MITOCHONDRION
卷 10, 期 6, 页码 649-661出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2010.06.003
关键词
Mitochondria; Manganese superoxide dismutase; p53; Reactive oxygen species
资金
- NCI NIH HHS [R01 CA139843] Funding Source: Medline
Coordination of mitochondrial and nuclear activities is vital for cellular homeostasis and many signaling molecules and transcription factors are regulated by mitochondria derived reactive oxygen species (ROS) to carry out this interorganellar communication The tumor suppressor p53 regulates myriad cellular functions through transcription-dependent and independent mechanisms at both the nucleus and mitochondria p53 affect mitochondria! ROS production in part by regulating the expression of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) Recent evidence suggests mitochondrial regulation of p53 activity through mechanisms that affect ROS production and a breakdown of communication amongst mitochondria p53 and the nucleus can have broad implications in disease development (C) 2010 Elsevier B V and Mitochondria Research Society All rights reserved
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