Manganese superoxide dismutase vs p53 Regulation of mitochondrial ROS

Coordination of mitochondrial and nuclear activities is vital for cellular homeostasis and many signaling molecules and transcription factors are regulated by mitochondria derived reactive oxygen species (ROS) to carry out this interorganellar communication The tumor suppressor p53 regulates myriad cellular functions through transcription-dependent and independent mechanisms at both the nucleus and mitochondria p53 affect mitochondria! ROS production in part by regulating the expression of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) Recent evidence suggests mitochondrial regulation of p53 activity through mechanisms that affect ROS production and a breakdown of communication amongst mitochondria p53 and the nucleus can have broad implications in disease development (C) 2010 Elsevier B V and Mitochondria Research Society All rights reserved