期刊
MITOCHONDRION
卷 10, 期 6, 页码 598-603出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2010.05.001
关键词
Mitochondria; Apoptosis; Cancer; Bcl 2 proteins
资金
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- Bundesministerium fr Bildung und Forschung Wilhelm-Sander-Stiftung
- Novartis Stiftung fr therapeutische Forschung the European Union (ApopTrain APO-SYS)
- [IAP6/18]
Mitochondria are key regulators of many forms of cell death and often altered in human malignancies Since the inefficacy of established cancer therapies is at least to a large extent the result of oncogenic blockade of cell death pathways compounds that directly affect mitochondrial functions are considered to present a promising alternative approach to eradicate chemotherapy-resistant cancer cells Since mitochondria targeted drugs can directly initiate mitochondrial perturbations independent of upstream signaling events these agents may Induce cell death and overcome drug resistance under circumstances where conventional drugs fail to act because pathways upstream of mitochondria are frequently disrupted in cancer cells A better understanding of the fundamental mechanisms that govern the complex processes of mitochondrial apoptosis is expected to open new perspectives for cancer drug development Hopefully this knowledge will eventually be translated into medical application for the treatment of human cancer (C) 2010 Elsevier B V and Mitochondrial Research Society All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据