期刊
MITOCHONDRION
卷 9, 期 1, 页码 1-8出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2008.10.003
关键词
Bax; Cyclosporin-A; Cytochrome-c; Mitochondrial membrane pore (MMP); Permeability transition pore (PTP); ANT; CypD; VDAC
Release of cytochrome-c from mitochondria is a key regulatory event in the intrinsic pathway of apoptosis, and its mechanism has been the subject of extensive debate with investigators proposing different and contrasting models. While some models suggest that cytochrome-c release can occur in absence of permeability transition and is mediated by the pro-apoptotic protein Bax, some suggest involvement of various components of permeability transition pore with or without cooperative action of Bax. Various models of PTP-dependent or -independent cytochrome-c release are discussed in this review with special emphasis on all the independent/cooperative roles of Bax evidenced so far. (C) 2008 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据