期刊
MITOCHONDRION
卷 9, 期 6, 页码 429-437出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2009.08.001
关键词
Mitochondrial disease; Respiratory chain; OXPHOS; Ribosome; Translation; Antibiotics
资金
- Israel Science Foundation [1354-2005]
- US-Israel Binational Science Foundation [032-2005]
- Hadassah-Hebrew University joint foundation
- National Institutes of Health [GM32734]
- United Mitochondrial Disease Foundation [05-20]
The infantile presentation of mitochondrial respiratory chain defects frequently simulates acute bacterial infection and sepsis. Consequently, broad spectrum antibiotic therapy is often initiated before definitive diagnosis is reached and without taking into consideration the potential harm of antibiotics affecting mitochondrial translation. Here, we demonstrate that some commonly used translation-targeted antibiotics adversely affect the growth of fibroblasts from patients with defective mitochondrial translation systems. In addition, we show that these antibiotics inhibit mitochondrial translation in vitro. Our results suggest that patients with mitochondrial translation defects may be more vulnerable to toxic-side-effects following the administration of certain translation-targeted antibiotics. (C) 2009 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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