期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 14, 期 5, 页码 426-443出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557514666140428105753
关键词
Cannabinoid receptors; CB2; GPCRs; selective ligand; structure-activity relationship
资金
- National Natural Science Foundation of China [NSFC 30973637]
- Qianjiang talents project of technology office in Zhejiang province [2010R10048]
Cannabinoid receptors, belonging to the superfamily of G-protein coupled receptors, play a major role in pathophysiology of a wide range of disparate diseases. Cannabinoid CB2 receptor, which mainly locates in peripheral tissues, represents as a promising drug target for the treatment of pain, osteoporosis, liver disorders, and so on without serious CNS side effects. In the past decades, the identification and optimization of selective ligands for the CB2 receptor has been a major objective in drug discovery. In the present review, we describe recent advances in the development of novel chemotypes of the CB2 receptor selective ligands, and give a simple discussion for the corresponding structure-activity relationships of them.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据