期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 13, 期 11, 页码 1626-1655出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/13895575113139990069
关键词
Antifungal agent; Antimycotic agent; Imidazole; Structure-Activity Relationship study
资金
- Maharishi Markandeshwar University, Mullana, India
Imidazoles are one of the most promising and vigorously pursued areas of contemporary antifungal chemotherapy depicting broad spectrum and potent activity. They have relatively simple molecular nucleus, which is amenable to many structural modifications. These agents have several favorable properties such as excellent bioavailability, good tissue penetrability and permeability and a relatively low incidence of adverse and toxic effects. They have been found effective in the treatment of various infectious diseases. This paper is an attempt to review the therapeutic potential of imidazoles as antifungal with an updated account on their development.
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