期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 12, 期 4, 页码 350-362出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955712799829258
关键词
Genistein; isoflavone; derivative; anticancer; molecular mechanisms; signaling pathways
资金
- National Natural Science Foundation of China [81102316]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [11KJD350002]
Genistein is the most abundant isoflavone in soybeans. It has exhibited diverse biological activities, among these, its anticancer effects is most noteworthy. Through regulating critical cell cycle genes, genistein can inhibit cancer cell growth in vivo and in vitro. It has been reported that genistein can inhibit activation of NF-kappa B and Akt signaling pathways to induce cell apoptlosis, both pathways are well known for their function to maintain a balance between cell survival and apoptosis. In order to find out more outstanding anticancer isoflavone agents, against cancers extended synthesis of genistein derivatives has been carried out. Some of these synthetic compounds demonstrated higher anticancer activity with lower doses. Based on these results, genistein and its synthetic derivatives may be an emerging new type of anticancer agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据