期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 10, 期 6, 页码 455-491出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955710791384045
关键词
3-Cl-AHPC; 4-HPR; AHPC; AHPN; apoptosis; cell-cycle arrest; retinoid-related molecule; SHetA2; ST1926
资金
- U.S. National Cancer Institute
- U.S. Veterans Administration
- California Tobacco-Related Diseases Research Program
Increasing evidence demonstrates that three classes of molecules originally derived from all-trans-retinoic acid and its synthetic analogues, which function by interacting with the retinoid nuclear receptors, exert their anticancer activities through alternative signaling pathways. Thus, the methylene-linked analogues (4-HBR, 4-HPRCG, and 4-HBRCG) of N-(4-hydroxyphenyl) retinamide (4-HPR) and its O-glucuronide metabolite (4-HPROG), the cinnamic acid analogues (3-Cl-AHPC and AHPC/ST1926) of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl)]-2-naphthalenecarboxylic acid, and N-(2,3-dihydro-2,2,4,4-tetramethyl-6-benzothiopyranyl), N'-(4-nitrophenyl)thiourea (SHetA2) induce cancer cell-cycle arrest and apoptosis mediated most likely through mitochondrial and/or endoplasmic reticulum stress responses. Structure-activity relationships and potential for clinical translation as anticancer therapeutics are presented.
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