4.5 Review

Distamycins: Strategies for Possible Enhancement of Activity and Specificity

期刊

MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 10, 期 3, 页码 218-231

出版社

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955710791185055

关键词

Liposomes; distamycins; antiproliferative activity; antitumor drugs

资金

  1. Fondazione Cassa di Risparmio di Cento
  2. Regione Emilia Romagna

向作者/读者索取更多资源

The present review focused on the strategies aimed to possibly solve toxicity problems of distamycins. Distamycins are compounds characterized by an oligopeptidic pyrrolocarbamoyl frame ending with an amidino moiety. This class of compounds displays antiviral and antibiotic activity and shows interesting antiprotozoal activity related to the ability to reversibly bind to the minor groove of DNA with a high selectivity for TA-rich sequences. In consideration of their potential therapeutic properties, the synthesis of new distamycin derivatives and especially the development of controlled delivery strategies, could lead to important advantages in the clinical use of these molecules, possibly overcoming or mitigating the low solubility, specificity and toxicity problems associated with their use. To these aims an ensemble of the main synthetic distamycin derived compounds and of the potential drug delivery systems for distamycins described in literature is reviewed.

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