期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 9, 期 6, 页码 696-702出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955709788452720
关键词
Quinolinones; anticancer activity; antibacterial activity; inhibition
资金
- Ministry of Schools, Youth and Education of the Czech Republic [MSM 6198959216, MSM 6198959223, LC07107]
- [A/CZ0046/1/0022]
2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones.
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