期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 9, 期 5, 页码 526-538出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955709788167619
关键词
Epidermal growth factor receptor; arterial hypertension; receptor transactivation; extracellular signal-regulated kinases; receptor tyrosine kinase inhibitors; leptin; metabolic syndrome
资金
- Medical University, Lublin, Poland [DS476]
Drugs which inhibit epidermal growth factor receptor (EGFR) are used in the treatment of cancers. EGFR may contribute to the development of hypertension by regulating vascular tone and renal Na+ handling. Synthetic EGFR inhibitors reduce blood pressure in some experimental models of hypertension suggesting that this receptor is a novel target for antihypertensive therapy.
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