期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 9, 期 11, 页码 1272-1283出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955709789878105
关键词
3-hydroxy-3-methylglutaryl-coenzyme A reductase; alpha-asarone; cardiovascular disease; low density lipoproteins; cholesterol; statins; side effects; structure-based drug design
资金
- EDI-IPN
- COFAA-IPN programs
High levels of cholesterol are a primary risk factor in the development of cardiovascular diseases. In this review, we have summarized the structural, chemical and computational aspects of hypocholesterolemic drugs, both statins and non-statins, that target enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) to block cholesterol biosynthesis.
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