期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 8, 期 9, 页码 943-951出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955708785132747
关键词
computer aided drug design; molecular modeling; structure-activity relationship; hormones; drug design; structure; QSAR; phytoestrogens
This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.
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