期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 8, 期 11, 页码 1163-1178出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955708785909880
关键词
G-quadruplex; G-quartet; ligands; substituted derivatives; affinity and selectivity; DNA interactions; telomerase inhibition
资金
- National Natural Science Foundation of China [20472117]
- Science Foundation of Zhuhai [PC20041131]
- Hong Kong Polytechnic University
- Shenzhen Science and Technology Fund
G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.
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