期刊
SCIENCE
卷 347, 期 6226, 页码 1155-1159出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1260943
关键词
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资金
- NIH [GM094780, DA023999, NS014841, F32 GM106628]
- Brown Cone Fellowship in the Medical Sciences
- NSF Graduate Research Fellowship
- Joint Medical Research Council (UK)/Wellcome Trust [099175/Z/12/Z]
- MRC [MC_PC_15004, G0700089] Funding Source: UKRI
- Medical Research Council [G0700089, MC_PC_15004] Funding Source: researchfish
Human higher cognition is attributed to the evolutionary expansion and elaboration of the human cerebral cortex. However, the genetic mechanisms contributing to these developmental changes are poorly understood. We used comparative epigenetic profiling of human, rhesus macaque, and mouse corticogenesis to identify promoters and enhancers that have gained activity in humans. These gains are significantly enriched in modules of coexpressed genes in the cortex that function in neuronal proliferation, migration, and cortical-map organization. Gain-enriched modules also showed correlated gene expression patterns and similar transcription factor binding site enrichments in promoters and enhancers, suggesting that they are connected by common regulatory mechanisms. Our results reveal coordinated patterns of potential regulatory changes associated with conserved developmental processes during corticogenesis, providing insight into human cortical evolution.
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