期刊
MICROVASCULAR RESEARCH
卷 95, 期 -, 页码 46-52出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mvr.2014.07.004
关键词
Lymphangiogenesis; Metastasis; Lymphatic endothelium; Immunoregulation; Chemokine; VEGF-C; VEGFR-3; CCL1; CCR8; Lymph node
资金
- NIH/NCI [R01 CA172637]
- U.S. Department of Defense Breast Cancer Research Program [W81XWH-12-1-0483]
- Susan G. Komen for the Cure [KG 110970]
- Exceptional Project grant from Breast Cancer Alliance
In cancer, lymphatic vasculature has been traditionally viewed only as a transportation system for metastatic cells. It has now become clear that lymphatics perform many additional functions which could influence cancer progression. Lymphangiogenesis, induced at the primary tumor site and at distant sites, potently augments metastasis. Lymphatic endothelial cells (LECs) control tumor cell entry and exit from the lymphatic vessels. LECs also control immune cell traffic and directly modulate adaptive immune responses. This review highlights advances in our understanding of the mechanisms by which lymphatic vessels, and in particular lymphatic endothelium, impact metastasis. (C) 2014 Elsevier Inc. All rights reserved.
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