期刊
MICROVASCULAR RESEARCH
卷 95, 期 -, 页码 108-115出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mvr.2014.08.001
关键词
Near-infrared spectroscopy; Wavelet coherence; Phase coherence; Functional connectivity; Cerebral infarction; Cerebral oxygenation; Spontaneous oscillations; Prefrontal cortex; Elderly; Resting state
资金
- National Natural Science Foundation of China [81071223, 31371002, 11272273]
This study aims to assess the prefrontal functional connectivity using wavelet coherence analysis of cerebral tissue oxyhaemoglobin concentration (Delta [HbO(2)]) signals in elderly subjects with cerebral infarction (CI) during the resting state. Continuous recordings of near-infrared spectroscopy (NIRS) signals were obtained from the left and right prefrontal lobes in 10 subjects with CI (age: 74.4 +/- 9.0 years) and 18 healthy elderly subjects (age: 69.9 +/- 7.3 years) during the resting state. The coherence between left and right prefrontal Delta [HbO(2)] oscillations in four frequency intervals (I,0.6-2 Hz; II, 0.145-0.6 Hz; III, 0.052-0.145 Hz and IV, 0.021-0.052 Hz) was analyzed using wavelet coherence analysis. In healthy elderly subjects, the Delta [HbO(2)] oscillations were significantly wavelet coherent in intervals land III (p < 0.05), wavelet phase coherent in intervals from I to IV. In elderly subjects with CI, the left and right Delta [HbO(2)] oscillations were significantly wavelet coherent and phase coherent in interval I (p < 0.05). In elderly subjects with CI, the power and phase coherences were significantly lower in interval III (p < 0.01) than in healthy subjects. The difference in wavelet coherence between the healthy elderly and elderly with CI indicates an altered brain functional connectivity in CI patients. This may be useful for assessing the effectiveness of functional recovery following a CI. (C) 2014 Elsevier Inc. All rights reserved.
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