期刊
MICROVASCULAR RESEARCH
卷 77, 期 3, 页码 265-272出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mvr.2009.01.010
关键词
Red blood cells; Blood flows; Cell free layer; Microcirculation; Hemodynamics; Hemorheology; Lattice Boltzmann method; Immersed boundary method
资金
- NIH [HL18292, HL079087]
- Natural Science and Engineering Research Council of Canada (NSERC)
- Laurentian University
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL018292, R01HL079087] Funding Source: NIH RePORTER
Concentrated erythrocyte (i.e., red blood cell) suspensions flowing in microchannels have been simulated with an immersed-boundary lattice Boltzmann algorithm, to examine the cell layer development process and the effects of cell deformability and aggregation on hemodynamic and hemorheological behaviors. The cells are modeled as two-dimensional deformable biconcave capsules and experimentally measured cell properties have been utilized. The aggregation among cells is modeled by a Morse potential. The flow development process demonstrates how red blood cells migrate away from the boundary toward the channel center, while the suspending plasma fluid is displaced to the cell free layer regions left by the migrating cells. Several important characteristics of microscopic blood flows observed experimentally have been well reproduced in our model, including the cell free layer, blunt velocity profile, changes in apparent viscosity, and the Fahraeus effect. We found that the cell free layer thickness increases with both cell deformability and aggregation strength. Due to the opposing effects of the cell free layer lubrication and the high viscosity of cell-concentrated core, the influence of aggregation is complex but the lubrication effect appears to dominate, causing the relative apparent viscosity to decrease with aggregation. It appears therefore that the immersed-boundary lattice Boltzmann numerical model may be useful in providing valuable information on microscopic blood flows in various microcirculation situations. (C) 2009 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据