期刊
MICROVASCULAR RESEARCH
卷 76, 期 3, 页码 139-144出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mvr.2008.06.004
关键词
Osteoprotegerin; Integrin alpha(v)beta(3); Integrin alpha(v)beta(5); Endothelial cells; Migration; Proliferation; Extracellular signal-regulated kinase
资金
- Grant-in-Aid for Scientific Research (C), Japan [18592064, 19592364]
- Grants-in-Aid for Scientific Research [18592064, 19592364] Funding Source: KAKEN
Osteoprotegerin (OPG) is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). However, the role of OPG in the endothelium remains unknown. In this study, we demonstrate that OPG stimulates the proliferation and migration of human microvascular endothelial cells (HMVECs). In addition, we show that treatment with integrin alpha(v)beta(3) or integrin alpha(v)beta(5) blocking antibody inhibits endothelial cell migration. In contrast, treatment with anti-alpha(v)beta(3) antibody or anti-alpha(v)beta(5) antibody alone did not inhibit OPG-induced proliferation. However, OPG-induced proliferation was inhibited when these antibodies were applied simultaneously. Furthermore, OPG evoked activation of extracellular signal-regulated kinase (ERK) 1/2, which has been linked to integrin alpha(v) activity. Taken together, these results suggest that integrins alpha(v)beta(3) and/or alpha(v)beta(5) contribute to endothelial cell proliferation and migration induced by OPG. (C) 2008 Elsevier Inc. All rights reserved.
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