期刊
MICROSCOPY RESEARCH AND TECHNIQUE
卷 73, 期 11, 页码 1019-1029出版社
WILEY
DOI: 10.1002/jemt.20829
关键词
computer-assisted microscopy; assisted histopathology; image registration
资金
- Spanish Ministry of Education [TEC2005-04732]
- Spanish Science and Innovation Ministry [MCIIN PSS-010000-2008-2]
- Marie Curie International Reintegration Grant [MIRG-CT-2005-028342]
- Department of Defense [DAMD17-00-1-0227, DAMD17-00-1-0306, 8WB-0150]
- University of California [DAMD17-00-1-0227, DAMD17-00-1-0306, 8WB-0150]
- CIMA, Spanish Ministry of Education
In this article, we present a novel method for the automatic 3D reconstruction of thick tissue blocks from 2D histological sections. The algorithm completes a high-content (multi-scale, multifeature) imaging system for simultaneous morphological and molecular analysis of thick tissue samples. This computer-based system integrates image acquisition, annotation, registration, and three-dimensional reconstruction. We present an experimental validation of this tool using both synthetic and real data. In particular, we present the 3D reconstruction of an entire mouse mammary gland and demonstrate the integration of high-resolution molecular data. Microsc. Res. Tech. 73: 1019-1029, 2010. (C) 2010 Wiley-Liss, Inc.
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