期刊
MICROSCOPY RESEARCH AND TECHNIQUE
卷 71, 期 10, 页码 703-709出版社
WILEY-LISS
DOI: 10.1002/jemt.20609
关键词
receptors; elastic artery; muscular artery; adenosine
资金
- FEDER and Fundacao Ilidio Pinho [POCI/SAU-FCF/60782/ 2004]
- Fundação para a Ciência e a Tecnologia [POCI/SAU-FCF/60782/2004] Funding Source: FCT
Adenosine plays an important role in the cardiovascular system, activating adenosine A(1), A(2A), A(2)B, and A(3) receptors, and regulating blood flow either by acting directly on vascular cells or indirectly because of its effects on the central or peripheral nervous systems. The aim of the present study was to investigate whether the pattern of distribution of adenosine receptor subtypes is different on elastic and muscular, using abdominal aorta and tail arteries as models. Immunohistochemistry using anti-A(1), anti-A(2A), anti-A(2B), and anti-A(3) receptor antibodies was performed on perfused-fixed/paraffin-embedded arteries from Wistar rats. 3,3'-Diaminobenzidine tetrahydrochloride (DAB; activated by hydrogen peroxide) staining revealed significant differences in the abundance of A,, A2A, and A3 receptors between abdominal aorta and tail artery and allowed the identification of distinct distribution patterns for A(1), A(2A), A(2B), and A(3) receptors in the tunica adventitia, media, and intima of muscular and elastic arteries. Data are compatible with several previous functional reports supporting that different adenosine receptor subtype expression and/or their distribution in the vessel wall may influence their respective contribution to the control of blood flow. Microsc. Res. Tech. 71:703-709, 2008. (C) 2008 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据