期刊
SCHIZOPHRENIA BULLETIN
卷 42, 期 2, 页码 344-357出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbv128
关键词
first-episode psychosis; age at onset; schizophrenia; bipolar disorder; cortical thickness; cortical volume; MRI
类别
资金
- Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III [PI081203, PI1101686]
- CIBERSAM
- Madrid Regional Government [S2010/BMD-2422 AGES]
- European Union [FP7-HEALTH-2009-2.2.1-2-241909, FP7-HEALTH-2009-2.2.1-3-242114, FP7- HEALTH-2013-2.2.1-2-603196, FP7- HEALTH-2013-2.2.1-2-602478]
- Fundacion Alicia Koplowitz [FAK2012, FAK2013]
- Fundacion Mutua Madrilena [FMM2009]
- ERA-NET NEURON (Network of European Funding for Neuroscience Research) [PIM2010ERN-00642]
- Instituto de Salud Carlos III, Spanish Ministry of Economy of Competitiveness
- Fundacion Alicia Koplowitz
Brain volume and thickness abnormalities have been reported in first-episode psychosis (FEP). However, it is unclear if and how they are modulated by brain developmental stage (and, therefore, by age at FEP as a proxy). This is a multicenter cross-sectional case-control brain magnetic resonance imaging (MRI) study. Patients with FEP (n = 196), 65.3% males, with a wide age at FEP span (12-35 y), and healthy controls (HC) (n = 157), matched for age, sex, and handedness, were scanned at 6 sites. Gray matter volume and thickness measurements were generated for several brain regions using FreeSurfer software. The nonlinear relationship between age at scan (a proxy for age at FEP in patients) and volume and thickness measurements was explored in patients with schizophrenia spectrum disorders (SSD), affective psychoses (AFP), and HC. Earlier SSD cases (ie, FEP before 15-20 y) showed significant volume and thickness deficits in frontal lobe, volume deficits in temporal lobe, and volume enlargements in ventricular system and basal ganglia. First-episode AFP patients had smaller cingulate cortex volume and thicker temporal cortex only at early age at FEP (before 18-20 y). The AFP group also had age-constant (12-35-y age span) volume enlargements in the frontal and parietal lobe. Our study suggests that age at first episode modulates the structural brain abnormalities found in FEP patients in a nonlinear and diagnosis-dependent manner. Future MRI studies should take these results into account when interpreting samples with different ages at onset and diagnosis.
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